When you hear an ambulance siren on the street, what do you do? You stop and pay attention! The siren isn't shouting for no reason; it's warning that something important is happening and that you need to make room or stay safe.
The Bible says God's Wisdom is like that: she "shouts" and "calls out loud" to warn us before we get hurt. When Mom or Dad say "don't do that!", that's Wisdom's siren working. Whoever listens stays safe. Whoever ignores it gets hurt!